The proportions of positive immunoreactions for MMP-2 and MMP-9 in ovarian tumor histological subtypes showed variations in the frequency of both metalloproteinases and, although no significant variations of MMP-2 were found in the epithelial location between histological subtypes, MMP-2 displayed a reduced frequency in the stroma compartments in high grade serous and endometrioid subtypes (Fig. 3). This evidence concerns the gene MMP2 and ovarian neoplasm.