The protective effect observed with the presence of MMP-2 in the stroma of the tumor could be explained by the secretion of anti-angiogenic factors [30], the production of chemoattractant for immuno-competent cells [31] or the increase in the secretion of TGFβ [32], all of which have been described to be associated with MMP-2. Here, TGFB1 is linked to neoplasm.