In agreement with its gene expression profile, adiponectin secreted levels were not affected by hyperinsulinemia in both the cell types (198 ng/ml in untreated vs 199 ng/ml in insulin-treated 3T3-L1, p = 0.911; 113 ng/ml in untreated vs 95 ng/ml insulin-treated SGBS, p = 0.086). This evidence concerns the gene ADIPOQ and hyperinsulinism.