The high levels of blood insulin and adjusted HOMA-IR in CAV1 KO mice on a HFD are in agreement with the augmented blood levels of C-peptide (Figure 2d), since C-peptide is secreted in equimolar concentrations with insulin, and increased levels of this peptide and insulin in the blood stream are indicative of insulin resistance [44,45]. The gene discussed is CAV1; the disease is Insulin resistance.