PLIN5 and metabolic dysfunction-associated steatotic liver disease: On the contrary, hepatocyte-derived LCN2 protects against diet-induced nonalcoholic fatty liver disease by regulating lipolysis, fatty acid oxidation, de novo lipogenesis, and apoptosis [37] or by interfering with expression of the lipid droplet associate protein Perlipin 5 (PLIN5) [38].