Based on our findings, we suggest that high cholesterol levels resulting in increased interaction of ERRα with PGC-1α and ERRα-PGC1α signaling provide protection against the production of ROS from oxidative stress by increasing cell detoxification enzymes like SOD2 and GSTM1, and thus help avoid irreversible damage on mitochondria and other organelles of cancer cells. This evidence concerns the gene PPARGC1A and cancer.