Moreover, early-stage CRCs can be grouped into four consensus molecular subtypes (CMS) in function of the driving gene alteration: MSI+ tumours with strong immune infiltration (CMS1), Wnt/beta-catenin proliferative tumours (CMS2) and KRAS mutated and metabolic-deregulated tumours with strong immune exclusion (CMS3), and “mesenchymal” tumours with stromal and innate immune infiltration (CMS4) [5,6]. Here, KRAS is linked to neoplasm.