Similarly, in vitro experiments using hydrogen peroxide to stimulate apoptosis have shown that knockdown of circ-ABCB10 has significantly suppressed proliferation and increased apoptosis of breast cancer cells due to the absence of sponging of miR-1271, indicative of a role of circ-ABCB10 in inhibiting apoptosis [16]. This evidence concerns the gene ABCB10 and breast carcinoma.