Secondly, there are a variety of features of NDV which are of relevance for resistance to therapy: (i) Potential to break T cell tolerance towards TAA expressing tumor cells, (ii) potential to break resistance to chemotherapy or radiotherapy, (iii) potential to break resistance to apoptosis, (iv) potential to break resistance to hypoxia, (v) potential to break resistance to TNF-related apoptosis-inducing ligand (TRAIL), (vi) potential to break resistance to immune checkpoint blockade, and (vii) potential to break resistance to anti-viral immunity [24,25]. The gene discussed is TNFSF10; the disease is neoplasm.