Among the four previously recognized molecular subtypes (classical, mesenchymal, neural, and proneural) [28], the mesenchymal subtype was associated with the SOH signature (p < 0.001 by chi-square test, Figure 2A), suggesting that the acquisition of the mesenchymal phenotype might be mediated by activation of YAP1/TAZ in GBM. The gene discussed is YAP1; the disease is glioblastoma.