Among them, we identified 48 protein features associated with the SOH signature many proteins known to be associated with poor prognosis in GBM, such as SERPINE1, FN1, CAV1, IGFBP2, HSPA1A, and SYK [34,35,36,37,38], were upregulated in the SOH subgroup, strongly suggesting potential cross-talk between the Hippo pathway and other signaling pathways associated with poor prognosis in GBM. This evidence concerns the gene IGFBP2 and glioblastoma.