Indeed, VEGF-A-expressing and Tie2-expressing macrophages produce highly localized vascular permeability thereby facilitating the extravasation of the tumor cells [88,89]; second, TAMs promote tumor growth by inhibiting both adaptive and innate antitumor immunity by secreting immunosuppressive molecules including TGFβ, IL10, arginase-1 (Arg-1) and NO [90,91,92,93]; third, TAMs are proangiogenic, thereby promoting tumor growth and recovery from cancer therapy. This evidence concerns the gene TGFB1 and cancer.