Given that resveratrol alone can decrease cellular proliferation by inducing G1 cell cycle arrest, cyclin D1 downregulation, and inactivation of AKT-GSK3β and ERK1/2 signaling [110], other studies have shown that resveratrol combined with gemcitabine chemotherapy is promising as a potential therapeutic option against pancreatic cancer [111,112,113,114]. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.