TNF and familial pancreatic carcinoma: Apigenin treatment decreased cell survival and increased apoptosis of AsPC-1, PANC-1 and MiaPaCa-2 pancreatic cancer cell lines through the inhibition of tumor necrosis factor-alpha (TNFα)-induced DNA binding (p65 and p50 subunits), resulting in reduced transcriptional activities of NF-kB [123].