One scRNA-seq study in samples from patients with melanoma identified a set of genes expressed in CAFs, such as those encoding complement proteins, whose expression correlated strongly with T cell infiltration; this implies that complement activity of CAFs is important for T cell recruitment and for modulating T cell-mediated anti-tumor immune responses (Markiewski et al., 2008; Tirosh et al., 2016). Here, VTN is linked to neoplasm.