TMBIM6 and infection: Based on our model that PTI-related ER stress triggers IBI1 translocation to the cytosol (Figure 7), it is tempting to speculate that binding of BABA to IBI1 affects FAH2-dependent BI-1 activity, resulting in increased sensitivity to PTI-related ER stress and augmented IBI1 translocation to the cytoplasm during pathogen infection.