The OR of colorectal cancer per SD increase of genetically predicted IGF‐1 levels was 1.22 (95% CI 1.09‐1.36; P = 3.9 × 10−4) when using the full set of SNPs (Figure 2) and 1.57 (95% CI 1.02‐2.41; P = .04) when using the SNP in the IGF1 gene. The gene discussed is IGF1; the disease is colorectal cancer.