First of all, conditional GRNs, i.e. normal GRN and cancer GRN, were constructed by using Boruta algorithm (Kursa and Rudnicki, 2010) based on candidate TF‒target relationships and mRNA expression data of 32 paired samples from The Cancer Genome Atlas (TCGA) CRC dataset (Vivian et al., 2017). This evidence concerns the gene TF and cancer.