RUNX3 and cancer: Although RUNX3 was reported to be a tumor suppressor in CRC (Weisenberger et al., 2006; Soong et al., 2009), in TCGA CRC dataset, RUNX3 expression displays weak difference between normal and cancer (Supplementary Figure S6) and weak correlation with prognosis (HR = 1.125, 95% CI: 0.965‒1.312).