RUNX3 and colorectal carcinoma: We compared the predictive accuracy of 4-DysReg for OS with previously reported CRC expression signatures, including RUNX3 (Soong et al., 2009), ColoPrint (contains 18 genes) (Salazar et al., 2011), ColoGuideEx (contains 13 genes) (Agesen et al., 2012), ColoGuidePro (contains 7 genes) (Sveen et al., 2012), ColoFinder (contains 9 genes) (Shi and He, 2016), CRCassigner-30 (Sadanandam et al., 2013), CRCassigner-7 (Sadanandam et al., 2013), a 7-gene signature (Chen et al., 2017), and a 4-gene signature (Zou et al., 2015).