According to the Peng statistics[22], CDCA1 expression is 1.982-fold higher in OCC tissues compared to normal samples (P = 3.03E-9), Pyeon[23] observed 6.027-fold increase in CDCA1 across multiple HNSCC cancer samples (P = 4.64E-7), and Sengupta[24] found 4.267-fold in HNSCC tissues (P = 1.22E-5, Table 1). This evidence concerns the gene NUF2 and head and neck squamous cell carcinoma.