We explored the difference in cumulative survival between HNSCC, HNSCC-HPV-pos and HNSCC-HPV-neg and found that the HNSCC-HPV-pos subgroup showed significantly higher B cells, CD8+ T cells and neutrophil immune infiltrates, (P<0.05) which was related to CDCAs levels. The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.