Table 1 gives an overview of the observed minor allele frequencies and the genotype of the three main NOD2 mutations rs2066844 (p.Arg702Trp), rs2066845 (p.Gly908Arg), and rs2066847 (p.Leu1007fsX1008) in our CD patient cohort. The gene discussed is NOD2; the disease is Cowden disease.