BCL2 and cancer: The observed up-regulation of several miRNA (miR-381-3p, miR-93-5p, miR-16-5p and miR-497-5p) in cancer-infiltrated LVs may inhibit Vascular Endothelial Growth Factor (VEGF) expression or VEGF receptors, both directly and indirectly via Bcl-2 inhibition [42–45].