Activation of human PKR, has been linked to different neurologic disorders like Parkinson's disease (PD), Huntington's disease (HD) and AD (8, 10, 42, 43, 46, 49, 51), and inhibition of PKR attenuates neuronal loss, motor deficits and memory deficits in AD mice models (48, 58). This evidence concerns the gene EIF2AK2 and Huntington disease.