Alzheimer's disease (AD) is the most predominant tauopathy and the two main histopathological hallmarks in this disease are the presence of amyloid‐β plaques and neurofibrillary tangles (NFT) in the brain of the diseased, with the latter consisting of aggregated and hyperphosphorylated tau (23, 63). This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.