GCG and diabetes mellitus: 2018), hardly anything is known about the genetics of the glucagon secretion defects. With the advent of human iPSC‐derived glucose‐responsive α‐cells with electrophysiological properties that closely resemble those of primary human α‐cells (Peterson et al. 2020), it might be possible to compare glucagon secretion in response to hypoglycaemia and its relationship to electrical activity in α‐cells derived from diabetes patients with good glycaemic control and those with an elevated risk of hypoglycaemia.