TCF4 and keratoconus: These included known keratoconus loci: FNDC3B (rs7635832, pCH = 6.7 × 10−91, pCRF = 6.9 × 10−134), ZNF469 (rs28425635, pCH = 4.3 × 10−92, pCRF = 1.5 × 10−109), MPDZ (rs12686184, pCH = 7.0 × 10−86, pCRF = 5.6 × 10−96) and FOXO1 (rs11616662, pCH = 1.7 × 10−74, pCRF = 3.5 × 10−84); and FECD loci: TCF4 (rs11659764, pCH = 2 × 10−77, pCRF = 3.9 × 10−92), ATP1B1 (rs1200108, pCH = 6.2 × 10−53, pCRF = 2.8 × 10−41) and SLC25A22 (rs12223324, pCH = 2.4 × 10−15, pCRF = 1.1 × 10−31).