Central to AD disease pathology are two processes: the extracellular formation of senile plaques in the grey matter of the brain which are primarily composed of amyloid-β precursor protein (APP)-derived amyloid-β (Aβ) [5, 6], and intracellular accumulation of hyperphosphorylated tau/Microtubule-associated protein tau (MAPT) protein to form neurofibrillary tangles [7, 8]. This evidence concerns the gene APP and Alzheimer disease.