The effects of mutagens, site directed to mimic known variants can also be described, for example the interactome of MAPT/Tau (UniProtKB P10636) p.Pro618Leu variant (dbSNP:rs63751273) with a known link to frontotemporal dementia [64], which reduces the ability of MAPT/Tau to promote microtubule assembly and accelerates aggregation of tau into filaments has been compared to that of the wild-type protein (IntAct:EBI-20800792/EBI-20799058) [65]. The gene discussed is MAPT; the disease is frontotemporal dementia.