Terms such as ‘regulation of amyloid-beta formation’, ‘regulation of synaptic plasticity’, ‘astrocyte activation’ (linked to AD pathology [68]), and child terms of Notch1 signaling (known to be altered in AD [69]) were overexpressed in comparison to a full list of human brain proteins, suggesting that this is a biologically relevant network. This evidence concerns the gene NOTCH1 and Alzheimer disease.