In the murine NOD MyD88-/- model of type I diabetes, the disease-associated enrichment of fusobacteria encoding a peptide with homology to the islet-specific glucose-6-phosphate catalytic subunit-relate (IGRP) protein, reportedly drove activation of IGRP-reactive CD8+ T cells that promoted development of diabetes (Tai et al., 2016). Here, MYD88 is linked to diabetes mellitus.