SLC8A1 and Parkinson disease: Specifically, that both circSLC8A1 and the linear SLC8A1 mRNA are upregulated during neuronal differentiation could suggest that changes in circSL8A1 expression in the PD brains might be related to cellular insults or challenges reported to selectively occur in dopaminergic neurons, such as oxidative stress, a known hallmark of PD (Farrer, 2006; Burbulla et al, 2017).