The SNPs and deletion polymorphisms in promoter and exonic regions of IRGM have been shown to be strongly associated with susceptibility to Crohn's disease and other autoimmune diseases (McCarroll et al, 2008; Brest et al, 2011; Xia et al, 2017; Yao et al, 2018). The gene discussed is IRGM; the disease is Crohn disease.