Because of systemic induction of ISGs, again the top functions and diseases associated with Irgm1 deficiency in brain and BMDMs were the antiviral response, systemic autoimmune syndrome (systemic lupus erythematosus, Sjogren's syndrome, psoriasis), rheumatic diseases, and other inflammatory disorders (Fig 1G, Appendix Fig S1F, and Dataset EV2). This evidence concerns the gene IRGM and rheumatic disorder.