Another study documented that in tumor cells deficient of von Hippel-Lindau (VHL) factor, a component in the E3 ubiquitin ligase complex that marks HIF-2α for degradation, activation of the HIF-2α pathway increases mTORC1′s activity by upregulating the expression of LAT1 (Elorza et al., 2012). Here, EPAS1 is linked to neoplasm.