ACHE and Alzheimer disease: For instance, the treatments available now in the market for AD consists of three inhibitors of acetylcholinesterase (AChEIs, Figure 1), which maintain the levels of acetylcholine (ACh) and thus the neurotransmission [17]; along with Donepezil, Galantamine, and Rivastigmine (2-4, Figure 1) approved for mild-to-moderate AD, one NMDA antagonist, Memantine (5, Figure 1), has been approved for moderate-to-severe AD [18].