TARDBP and amyotrophic lateral sclerosis: In ALS, histological studies have shown the presence of aggregates of mutant superoxide dismutase 1 (SOD1), TAR DNA binding protein (TDP-43), fused in sarcoma (FUS), and repeat dipeptides from noncanonical translation of mutant chromosome 9 open reading frame 72 (C9ORF72) [6].