- Stable PCSK9DY mRNA expression - Persistent IDL/LDL hyperlipidemia - No long-term breeding needed to generate the model - Can be performed in different genetic backgrounds, but C57BL/6J seems to be most susceptible to PCSK9DY - Synergistic effect of ApoE−/− and PCSK9DY. This evidence concerns the gene APOE and hyperlipidemia.