CDH1 and cancer: E-cadherin is a major component of the adherens junctions that maintain cell-cell adhesion, basal-apical polarity, and epithelial tissue homeostasis, thus restraining cell motility and cancer progression (Perl et al., 1998; Izaguirre and Casco, 2016; Kourtidis et al., 2017; Carneiro et al., 2019).