SPHK1 and melanoma: Augmented endocytosis of E-cadherin has also been reported (Jones et al., 2006; Kourtidis et al., 2017) and autophagy-induced degradation, due to overexpression of SIRT1, SPHK1, or PHF8 have been described in melanoma and hepatocarcinoma (Liu et al., 2017; Sun et al., 2018; Zhou et al., 2018).