CASP3 and childhood gender nonconformity: Interestingly, the 10 min level of mitochondria membrane depolarization (Figure 7C), the changes in the [Ca2+]i (Supplementary Figure S6), and the extent of the reduction in the luminal [Ca2+]ER (Supplementary Figure S7) did not show any correlation with the activation of caspase-3 in CGN.