Based on this, they proposed that JQ1 can directly target the EWS-FLI1 gene, releasing BRD4 from the EWS-FLI1 promoter, thereby resulting in down-regulation of EWS-FLI1 gene expression and inhibiting the progression and metastasis of Ewing sarcoma (Jacques et al., 2016). This evidence concerns the gene FLI1 and Ewing sarcoma.