Affer et al. (2014) proposed that the MYC locus in MM has a loose rearrangement of enhancers and SEs that causes dysregulation of MYC. They proposed that rearrangement like this reposition of MYC nearby the genes related to SEs accelerates the progress of MM (Affer et al., 2014). The gene discussed is MYC; the disease is Miyoshi myopathy.