Jin et al. (2018) described the regulatory elements and TF footprint in primary MM cells by RNA-seq and ChIP-seq assay. They established a SE-related TF-based regulatory network and identified several novel TFs critical for the biology of MM based on the newly established regulatory network. Their study indicated that IRF4 and FLI1 showed significant overlap with 92% of all SEs in MM cells and could promote the growth and proliferation of MM. The gene discussed is IRF4; the disease is Miyoshi myopathy.