BRD4 and infection: It is known that within the first 8 h of permissive infection with clinical isolates of HCMV, BRD4 along with CycT1 and CDK9 (the RNAPII-activating P-TEFb complex) accumulate at nuclear sites, known as the transcriptosome, where the transcriptionally active HCMV genome resides (Kapasi and Spector, 2008).