Other enriched categories in ObCRC network are: (i) TGF-beta signaling that has been reported to regulate multiple aspects of AT biology (i.e., vascularization, inflammation and fibrosis) (89), (ii) Netrin-1 signaling, recently described to play a role in tissue regulation outside the nervous system, specifically in tumor development (i.e., angiogenesis and inflammation) and (iii) PTEN regulation, for which a dual role as tumor suppressor and metabolic regulator has been reported (90). The gene discussed is PTEN; the disease is neoplasm.