Further, in Ob individuals, we found enriched cancer pathways shared with CRC lean subjects (e.g., Signaling by FGFR1, Pathway in clear cell renal cell carcinoma, Integrated Breast Cancer Pathway), or unique of obese condition, such as a TP53-related pathway, all induced (Figure 6B). This evidence concerns the gene TP53 and clear cell renal carcinoma.