Among the miRNAs dysregulated in obese subjects compared to the normal weight controls, we found those involved in adipogenesis (e.g., let-7 family, miR-193b,−483-5p), in lipid metabolism (e.g., miR-181d), or in glucose and insulin metabolism (e.g., miR-34a-5p,−24-3p,−144-5p,−361-3p), previously described in different AT depots of obese subjects (9, 57–59), further supporting a role of these miRNAs in the functional alterations of adipocytes occurring in obesity. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.