INS and neoplasm: Finally, the ObCRC network (Figure 6C) was primarily enriched by fundamental biological functions that are implicated in inflammatory signaling pathway (e.g., Platelet degranulation, TGF-beta signaling, IL-4, and IL13 signaling), tumor suppression and insulin sensitivity (e.g., Regulation of PTEN gene transcription, Interleukin-37 signaling, Insulin resistance), along with categories related to metabolism (e.g., Pyruvate metabolism and Citric Acid cycle, AMPK signaling) and cancer (e.g., FGFR1 mutant receptor activation; signaling by VEGF).