KDM5C and intrahepatic cholangiocarcinoma: Furthermore, we monitored cellular oxygen consumption rates (OCR) by using oligomycin, FCCP, rotenone/antimycin A. We found that the OCR was significantly decreased in the KDM5C-overexpressing ICC cells compared with control cells (Figure 3M), suggesting that cellular bioenergetics metabolism was inhibited by abnormal expression of KDM5C.