Nevertheless, it has been observed that breast CAFs secrete a large number of growth factors such as fibroblast growth factor (FGF), transforming growth factor beta (TGF-β), CXCL12, and hepatocyte growth factor (HGF), as well as various cytokines that contribute to cancer cell proliferation, invasiveness and angiogenesis (76). The gene discussed is HGF; the disease is cancer.