However, the two most significantly differentially expressed genes in the breast cancer epithelia between AA and EA patients are the phosphoserine phosphatase like (PSPHL) and Beta-crystallin B2 (CRYBB2) (55).Interestingly, PSPHL and CRYBB2 are also the most differentially expressed genes in prostate cancer patients from these two ancestral backgrounds (108). This evidence concerns the gene PSPHP1 and prostate cancer.