CRYBB2 and Familial prostate cancer: However, the two most significantly differentially expressed genes in the breast cancer epithelia between AA and EA patients are the phosphoserine phosphatase like (PSPHL) and Beta-crystallin B2 (CRYBB2) (55).Interestingly, PSPHL and CRYBB2 are also the most differentially expressed genes in prostate cancer patients from these two ancestral backgrounds (108).