As shown in Figure 9A, at three concentration of BD, 0.1, 0.5, and 1.5 μM, the expression of ZFP36 and EGR1 mRNA were increased in MCF-7 and MDA-MB-231 cells in a dose-dependent manner, while the level of FOS mRNA was significantly reduced in a concentration-dependent manner in MCF-7 and MDA-MB-231 breast cancer cells. The gene discussed is EGR1; the disease is breast carcinoma.