For example, Vanin‐1‐deficient mice display alleviated inflammation in the intestine of the colitis model.[18] However, these mice have increased insulitis in the pancreatic islets when challenged by streptozocin (STZ).[33] This inconsistency suggests that the physiological roles of Vanin‐1 are tissue‐specific and are dependent on the tissue per se functions. Here, VNN1 is linked to colitis.