Obesity is associated with macrophage infiltration in adipose tissues, causing the chronic inflammation and insulin resistance.[25] As shown in Figure S3M of the Supporting Information, IHC analysis showed stronger staining signals for F4/80 (markers of macrophage infiltration) in abdominal WAT of HFD‐fed Vanin‐1−/− mice. This evidence concerns the gene VNN1 and obesity due to melanocortin 4 receptor deficiency.