Therefore, studies in fasted and HFD‐fed mice in the Vanin‐1 deficient background suggest that Vanin‐1 is a bona fide regulator of lipolysis in the abdominal adipose tissues, and Vanin‐1 deficiency blunts lipolysis, leading to the aggravated metabolic syndromes in HFD‐fed mice. This evidence concerns the gene VNN1 and metabolic syndrome.