PIGF and female infertility: Pigf encodes phosphatidylinositol glycan anchor biosynthesis class F, which is involved in glycosylphosphatidylinositol (GPI)‐anchor biosynthesis.[61] Abrogation of GPI anchor biosynthesis in oocytes causes fertilization failure and female infertility,[62] which indicates that the presence of GPI‐anchored proteins on oocyte surface is critical for oocyte development.