RHO and cancer: Accumulating evidence indicates that Rho family GTPases are involved in promoting the proliferation, cytokinesis, cell cycle progression, metastasis and invasion of cancer cells.[2, 10, 11] As Rho family proteins are essential for the migration and invasion of cancer cells, their inhibitors have great potential to become drug candidates to target cancer metastasis,[12] a leading cause of cancer recurrence and chemotherapy failure.