RHO and cancer: Elevated Rho GTPase activity has been reported to play a key role in the hyper‐proliferative and invasive behaviors of cancer cells.[27, 28] Thus we evaluated the ability of DC‐Rhoin04 to inhibit cellular Rho activity and Rho‐mediated cell migration and invasion in MDA‐MD‐231 cells, a highly aggressive triple‐negative breast cancer cells.[29] The cellular activity of RhoA was assessed by quantification of the amount of GTP‐loaded RhoA from cellular lysates using RBD pull down assay.