CRH and Anxiety: In the single study conducted with females—who had anxiety and AUD—the CRF Subscript 1 receptor antagonist verucerfont reduced HPA responsivity without altering measures of alcohol craving.91 Considering the preclinical data indicating that CRF Subscript 1 receptor antagonists effectively reduce escalation in alcohol drinking in dependent male rodents, it is not known whether verucerfont would reduce measures of alcohol drinking in females with AUD.