Third, in mice deficient in beta-endorphin (knockout mice), a peptide that regulates HPA axis activity via mu opioid receptor–mediated inhibition, the females had elevated basal levels of anxiety, plasma corticosterone, and CRF in the extended amygdala when they were compared with female wild-type mice.97 High binge alcohol intake in the female beta-endorphin knockout mice normalized their high levels of basal anxiety, corticosterone, and CRF. The gene discussed is OPRM1; the disease is Anxiety.