Qian et al. (2014) had shown that the methylated +58CpG in DCN 5′-UTR involved in reduced the mRNA expression of DCN. In our research, Fibromodulin (FMOD) acted as an important mediator in VEGF expression and angiogenesis induced by GDNF in human glioblastoma (Chen et al., 2018). This evidence concerns the gene VEGFA and glioblastoma.