IRF7 and Familial prostate cancer: It has been shown that Irf7 repression promotes bone metastasis through immune escape in a mouse model of breast cancer bone metastasis.27 Moreover, overexpression of IRF7 inhibited prostate cancer cell-mediated bone metastasis in mice,40 suggesting a common role of the Irf7 axis in bone metastasis mediated by different types of malignancies.