It has been pointed out that the histopathological manifestations in the brains of PD patients harboring FPD mutations in LRRK2 are pleiotropic, ranging from pure nigral degeneration without α-synuclein deposition [16,17,20], to dementia with LB (DLB)-like widespread α-synuclein pathology [8,15]. This evidence concerns the gene LRRK2 and Parkinson disease.