Whereas little is known about the causal association between Rab phosphorylation by LRRK2 and neurodegeneration in PD, Jeong and colleagues [112] found that the overexpression of Rab1A T75A mutant, Rab3C T94A mutant, as well as Rab35 T72A and T72D mutants caused TUNEL-positive apoptosis in primary neurons. Here, LRRK2 is linked to Parkinson disease.