This is in line with our finding of a concurrent increase in both Lingo-1 and Myt1 protein expression in the postmortem DLPFC of schizophrenia patients compared with controls [31], and is further supported by a study that has identified microduplications in the Myt1l gene in 2% of childhood onset schizophrenia subjects from the largest cohort of very-early onset childhood onset schizophrenia subjects to date [57]. This evidence concerns the gene MYT1L and Rare pervasive developmental disorder.