We demonstrated that inclusion of CD8α ALN-1 in a prime-boost model of prophylactic influenza vaccination with whole-inactivated H3N2 virus protects mice against challenge with a heterosubtypic pH1N1 virus to the same extent as WT IL-1β, whereas most of the mice that had been vaccinated without adjuvant rapidly succumbed to infection-induced disease. Here, CD8A is linked to influenza.