Furthermore, this GO analysis indicated that genes associated with the antiviral response to influenza (e.g., Ifi27l2a, Isg20, Oas1a, Isg15, Ifit1, Oasl1, and Ifit3) were strongly enriched in mice vaccinated with WIV alone as compared with mice vaccinated with WT IL-1β or CD8α ALN-1. The gene discussed is ISG15; the disease is influenza.