NLRP3 and Parkinson disease: In a PD mouse model treated with the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), compared with wild-type mice, the progression of PD in NLRP3-/- mice is suppressed, which also illustrates the connection between NLRP3 inflammatory bodies and PD [39].