GRK4 and Hypertension: Variants of the AT1 receptor of angiotensin II (AGTR1) [21] and other genetic polymorphisms such as the G protein-coupled receptor kinase 4 (GRK4) [22, 23] and solute carrier family 12 member 3, SLC12A3 [24], have been related to arterial hypertension and atherosclerosis.