Results of possible clinical parameters (BMI, HOMA-β, HOMA-S, QUICKI, HbA1c, TAG, TC, insulin, LDL-C, HDL-C, LDL-C/HDL-C, TC/HDL-C, and TAG/HDL-C) effect on asprosin indicated that FBG and HOMA-IR independently associated with serum concentrations of asprosin in T2DM. The gene discussed is INS; the disease is type 2 diabetes mellitus.