BACE1 and Alzheimer disease: ICT (C21H22O7, MW: 386.4) and icaritin (ICA, C33H40O15, MW: 676.67) are active ingredients of flavonoids extracted from Epimedium. Our previous studies have shown that ICT exerts anti-AD effects by activating adenosine 5′-monophosphate-(AMP-) activated protein kinase (AMPK) and inhibiting BACE-1 [10].