TYR and melanoma: PME promoted melanin production, tyrosinase activity, and the expression of melanogenic genes, such as MiTF and tyrosinase (Figures 2 and 3) in B16F10 cells, as previously reported in mouse B16 cells [11, 19], rat dermal papilla cells [16], human foreskin melanocytes [17], and human melanoma SK-MEL-18 cells and zebrafish [18].